https://doi.org/10.1140/epjh/s13129-021-00013-w
Regular Article
The breakthrough of a quantum chemist by classical dynamics: Martin Karplus and the birth of computer simulations of chemical reactions
1
Department of History of Science, Technology and Medicine, Peking University, 100871, Beijing, China
2
Neubauer Collegium for Culture and Society, University of Chicago, 60637, Chicago, IL, USA
3
Department of Biochemistry and Molecular Biology, University of Chicago, 60637, Chicago, IL, USA
4
Department of Physics, University of Rome, 00185, Rome, “La Sapienza”, Italy
5
IAC-CNR, Institute for the Application of Computing “M. Picone”, National Research Council, 00185, Rome, Italy
6
School of Physics, University College Dublin, Belfield, 4, Dublin, Ireland
Received:
19
December
2020
Accepted:
26
March
2021
Published online:
10
June
2021
1964–1965 was an early, crucial period in Martin Karplus’ research—a time when, rather unexpectedly, he approached the problem of reactive collisions using a quasiclassical approximation with the aid of computer technologies. This marked a substantial departure from the quantum-chemical studies of nuclear magnetic resonance that had, until then, dominated his work. The historical perspective outlined by George Schatz, as well Karplus’ own biography, partly frames the contours of this remarkable period in the history of theoretical chemistry. Yet, the available historical literature is not sufficiently complete to allow us to understand Karplus’ transition from nuclear magnetic resonance to reaction dynamics. In this article, we discuss the intellectual ground on which Karplus operated around 1964, further commenting on the relevance of his quantum and quasiclassical studies and pondering how Karplus’ approach eventually led to his interest in the simulation of complex biomolecules.
© The Author(s) 2021
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